Pre-Conference Workshop Day - Tuesday, January 25
Workshop A | 08:30am - 11:30pm PST
Understanding & Choosing the Appropriate Humanized Mouse Platform for Your Drug Development Needs
In this interactive workshop hosted by the Jackson Laboratory, you will learn the latest advancements of humanized mouse models - and how this can help you progress immuno-oncology candidate through the pipeline.
1. What is a humanized mouse? Approaches to humanization to understand main characteristics, advantages, and limitations of current platforms
a. Genetic humanization and creation of host strains
b. Human PBMC humanization
c. Human CD34 HSC humanization
2. Applications of human immune cell engrafted mice
a. Xenogeneic GvHD, a versatile platform for drug discovery in immune activation and suppression
b. Immuno-oncology
• Check point inhibitors
• Cell depletion
• Multi-specific antibodies
• CAR-T, NK, Macrophage
3. Safety and toxicity; in vivo assay for cytokine release syndrome
4. Round table discussion: Find out from experts and colleagues the details you need to apply these valuable tools for your research and drug discovery
Hosted By:
Workshop Leaders:
Workshop B | 12:30pm - 13:30pm PST
Challenges in Development and Implementation of Mouse Models for Evaluation of Novel T-Cell Based Therapeutics
Join us in this 1 hour workshop to hear from CERo Therapeutics in a short presentation on the challenges in development and implementation of mouse models for evaluation of novel T-Cell based therapeutics. This is your opportunity to discuss key issues and points raised in the presentation and ask your burning questions.
Workshop Leaders:
