Company: Cedars-Sinai Medical Center & UCLA
Job title: Associate Professor
Joshua Breunig, PhD, is an Associate Professor at Cedars-Sinai Medical Center with a joint appointment in the Department of Medicine at the David Geffen School of Medicine at UCLA. Dr. Breunig received his Ph.D. from Yale University in the lab of Dr. Pasko Rakic, co-recipient of the inaugural Kavli Prize in Neuroscience—where he also completed postdoctoral work. The Breunig lab has recently created a new methodology for creating “personalized” tumors in immunocompetent animal models and human organoids—termed mosaic analysis with dual recombinase-mediated cassette exchange (MADR). These MADR tumor models are ideal for use as pre-clinical platforms for discovery, testing, and validation of novel therapeutics, including small molecules and immunotherapies. Dr. Breunig is supported by funding from the American Cancer Society, and NCI; and was recently designated as a “Nextgen Star” by the American Association of Cancer Research.
Discussion/Q&A 2:30 pm
day: Day Two
MADR: Multiplex In Vivo and In Vitro Genetically Engineered Tumor Models for Immuno-Oncology Preclinical Discovery & Testing 1:30 pm
Using mosaic analysis with dual recombinase-mediated cassette exchange (MADR) to generate “personalized” tumor subtypes Diversifying the use of MADR for the generation of autochthonous in vivo modelling, syngeneic modelling, and multiplex organoid modelling of tumors Employing MADR as preclinical platforms for immuno-oncology testing and discoveryRead more
day: Day Two