Validating IO Bispecific Antibodies in Humanized Models

Time: 9:00 am
day: Day Two


  • Targets of the innate immune system are less evolutionarily conserved than the adaptive immune system, presenting challenges in pre-clinical testing
  • Use of genetically engineered models and humanized mice are novel approaches to test therapeutics to these targets
  • AL008 is a bi-functional antibody that antagonizes SIRPa, a myeloid checkpoint receptor, and activates Fc receptor signalling, and induces tumor regression as a monotherapy and a combination therapy in pre-clinical models