January 23-25, 2018

San Francisco, CA

 

Day One
Wednesday January 24th, 2017

Day Two
Thursday, January 25th 2018

08.00
Registration

09.00
Chairperson’s Opening Remarks


ENHANCING PRECLINICAL STRATEGIES FOR DEVELOPING CANCER IMMUNOTHERAPIES THROUGH NEXT GENERATION PRECLINICAL RESEARCH


09.10
Patient-Derived Tumor Xenografts in Humanized NSG-SGM3 Mice: A New Immuno-Oncology Platform

  • James Keck Senior Director for the Clinical Lab & In Vivo Pharmacology Services, The Jackson Laboratory

Synopsis

  • The addition of 3 human cytokines (GM-CSF, IL-3 & Kit Ligand) into the NSG mouse provide for a more robust myeloid compartment after humanization
  • Showcase data on the myeloid engraftment kinetics and also show checkpoint inhibitor efficacy against several PDX tumors

09.40
Preclinical Modeling of Diverse Brain Tumor Subtypes via Single-Copy Somatic Transgenesis and CRISPR Genome Editing

Synopsis

  • Overview of novel genetic methodologies for rapid, autochthonous tumor modeling
  • Strategies for combining single-copy somatic transgenesis with CRISPR genome editing to generate patient-derived mutation signatures in mouse models to accurately model clinical tumor subtypes in a “personalized” manner
  • Examples of preclinical studies investigating strategies to impede tumor growth and development by immunotherapy, metabolic targeting, and therapeutic mimicry

10.10
Pre-clinical Modeling of Immune Responses to Cancer: From Bench-Side to Clinical Outcomes

Synopsis

  • Fundamental differences in immune composition, tumor microenvironments and disease progression between mice and humans.
  • Preclinical models in immune-oncology: what translates and what doesn’t.
  • How to leverage the data from pre-clinical studies and minimize translational failures.

10.40
Developing checkpoint target humanized models for preclinical efficacy assessment

  • Toni Jun Director of Scientific Engagement , Crown Bioscience

Synopsis

  • Lack of animal models for efficacy evaluation of human therapeutic antibodies for cancer Immunotherapies
  • HuGEMM models, expressing chimeric checkpoint targets with human extracellular domains, allow the evaluation of specific human biological therapies in vivo

11.10
Speed Networking

11.40
Morning Refreshments

12.10
Utilising 3D Tumor Models Built With Scalable Bioprinting Technology to Improve Cancer Drug Development

Synopsis

  • A new type of 3D bioprinting technology for screening
  • Patient-derived tumor testing for precision medicine
  • Assaying immuno-oncology in 3D


ENHANCING THE POWER OF PREDICTIVE PRECLINICAL RESEARCH TO FORWARD THE CLINICAL SUCCESS OF YOUR ADOPTIVE CELL THERAPIES


12.40
T Cell Co-Stimulation: A Potent Pathway for Improved Adoptive Cell Therapy

Synopsis

  • Tumor Infiltrating Lymphocytes (TIL) therapy) and its impact on the melanoma patients
  • Ex-vivo reprogramming of T cells for improved therapy
  • Learn how to test these reprogrammed TILs in In vivo mice model

13.10
Understanding T cell Exhaustion in Common Syngeneic Tumor Models

Synopsis

  • Co-expression of the inhibitory receptors PD1/LAG3/TIM3 enriches for highly activated CD8 T cells in established syngeneic tumor models
  • Reduced functionality of TILs is observed in the PD1- population rather than the PD1+ CD8 T cell subset.
  • Caution must be exercised when using inhibitory receptor expression alone to define T cell functionality in commonly used syngeneic tumor models

13.40
Lunch


MINIMIZING THE TRANSLATIONAL GAP FROM PRECLINICAL TO CLINICAL THROUGH NEXT GENERATION IN VIVO MODELS


14.40
Optimizing In Vivo Models for the Development of Autologous T cell Therapies

  • Shon Green Preclinical Development, Eureka Therapeutics

Synopsis

  • What models are being utilized to evaluate efficacy of engineered T-cell therapies?
  • How do we overcome the limitations of immune-compromised mice?
  • Characterizing your T cells in vivo to extract correlates with efficacy

15.10
Circulating Tumor Cell (CTC) Analysis in Preclinical Models of Cancer Metastasis

  • Lori Lowes Post-Doctoral Research Fellow, London Health Sciences Centre

Synopsis

  • In the development of novel cancer therapies, there is a critical need for in vivo preclinical models that will allow assessment of metastasis.
  • A number of quantitative tools have been previously developed to study in vivo metastasis, the detection and quantification of rare metastatic events has remained challenging.
  • This presentation will discuss the use of circulating tumor cell (CTC) analysis as an effective means of tracking and characterizing metastatic disease progression in preclinical mouse models of breast and prostate cancer.
  • In particular, the use of clinically-relevant CTC technologies such as the Parsortix platform (ANGLE plc) can serve to enhance the translation of cancer biology and new cancer therapies from animal to patient.

15.25
Advanced PDX Tumor Biology Platforms for Drug Advancement

  • Neal Goodwin Vice President, Corporate Research & Development, Champions Oncology

Synopsis

  • Harnessing large collections of PDX models for more resolute efficacy predictions and the discovery of new therapeutic targets, resistance mechanisms, and biomarker signatures of response
  • How robust systems of myeloid engraftment, including hematopoietic stem cells for immune-oncology modeling and AML engraftment for high throughput multipatient in vivo screens, have now provided expanded PDX screening with a wider scope of therapeutic agents
  • Advancement of coupled-PDX trials, where clinical trials are combined with companion PDX studies to help guide follow-on trial design

15.55
Afternoon Refreshments

16.25
Humanized mouse models for drug discovery research

Synopsis

  • Development of humanized in vivo models to develop IO therapeutics
  • Explore the advantages and limitations of humanized vs syngeneic systems
  • Leveraging humanized systems for deciphering mechanism of action and clinical translation

16.55
Chairperson’s Closing Remarks

17.00
Drinks Reception Hosted by The Jackson Laboratory